Emsam is a prescription medication primarily used to treat major depressive disorder (MDD). What makes Emsam different from many other antidepressants is that it’s delivered through a transdermal patch, which means the medication is absorbed through the skin and enters the bloodstream directly. This method can offer advantages for individuals who have not responded well to oral medications or who experience side effects from traditional antidepressants.
At My Psychiatrist, we understand that every patient responds differently to medications. That’s why we offer a variety of treatment options, including newer alternatives like Emsam, which may be part of a personalized approach to treating depression and related symptoms.
What Is Emsam?
Emsam is the brand name for selegiline in patch form. It belongs to a class of drugs known as monoamine oxidase inhibitors (MAOIs), which work by increasing the levels of neurotransmitters such as dopamine, norepinephrine, and serotonin in the brain. These brain chemicals help regulate mood, and boosting their levels can reduce symptoms of depression.
Unlike older MAOIs, Emsam is the first and only transdermal MAOI approved by the FDA for the treatment of depression. Because it’s delivered via patch, it bypasses the digestive system, which may help reduce some of the dietary restrictions and gastrointestinal side effects typically associated with MAOIs.
What Emsam Treats
Emsam is primarily used to treat Major Depressive Disorder, especially in adults who have not found relief with other antidepressants. It may be considered when first-line SSRIs or SNRIs haven’t been effective or have caused intolerable side effects.
Though not formally approved for these uses, some psychiatric providers may consider Emsam off-label for conditions such as:
- Treatment-resistant depression
- Persistent mood disorders with fatigue or low motivation
- Depression accompanied by cognitive slowing or apathy
Because MAOIs affect a broad range of neurotransmitters, they can sometimes be helpful for patients whose symptoms include both emotional and physical features of depression.
How Emsam Works
Emsam works by inhibiting monoamine oxidase, an enzyme that breaks down neurotransmitters in the brain. By blocking this enzyme, Emsam allows more dopamine, norepinephrine, and serotonin to remain active in the brain, helping improve mood and emotional balance.
The patch is applied once a day, typically to the upper torso, upper thigh, or behind the ear. It’s important to rotate application sites to avoid skin irritation. The patch comes in different strengths, and your provider will determine the appropriate dose for you based on your needs and how you respond to the treatment.
What to Expect When Starting Emsam
Starting Emsam involves a careful conversation with your psychiatric provider, especially regarding medications, diet, and health history. One of the advantages of the lower-dose Emsam patch (6 mg/24 hours) is that it does not require dietary restrictions. However, at higher doses (9 mg or 12 mg), patients need to avoid foods high in tyramine, such as aged cheeses, cured meats, and certain wines, as these can cause dangerous increases in blood pressure when combined with MAOIs.
Early in treatment, some people may notice mild side effects including:
- Skin irritation at the patch site
- Insomnia
- Dizziness
- Mild nausea or headache
These effects often fade as your body adjusts. If any side effects are bothersome or persistent, we recommend reaching out to your provider promptly.
Symptoms Emsam May Help Relieve
Emsam may be effective in managing:
- Low mood or persistent sadness
- Lack of energy or motivation
- Difficulty concentrating
- Feelings of hopelessness
- Sleep disturbances tied to depression
- Anxiety symptoms in conjunction with depression
Because depression manifests differently in each person, Emsam may be particularly helpful for individuals who haven’t had success with other antidepressants and are looking for an alternative that works through a different biological pathway.
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FAQs About Emsam
Is Emsam a first-line treatment?
Emsam is usually considered after other antidepressants have been tried. However, it may be used earlier in certain situations depending on a person’s symptoms and treatment history.
Does Emsam have dietary restrictions?
The 6 mg/24 hour patch does not require dietary changes. Higher doses may require avoiding high-tyramine foods to prevent interactions.
How long does it take for Emsam to work?
Like many antidepressants, Emsam may take several weeks to show noticeable improvement. Most patients begin feeling better within 3–6 weeks, but timing varies.
Can I use Emsam with other medications?
Some medications and supplements interact with Emsam and can be dangerous. It’s crucial to share a full list of everything you take with your provider before starting.
Is Emsam safe for older adults?
It may be a good option for some older adults, especially those sensitive to oral medications. However, a provider will consider all health factors before prescribing it.
Can I stop using Emsam suddenly?
Discontinuing Emsam should always be done under medical supervision. Suddenly stopping can cause withdrawal symptoms or a return of depression symptoms.
Does Emsam cause weight gain or sexual side effects?
Emsam is generally considered to have a lower risk of weight gain and sexual dysfunction compared to some other antidepressants, but individual responses vary.
Personalized Care at My Psychiatrist
If you’re struggling with depression and haven’t found relief with traditional medications, Emsam may offer a promising alternative. At My Psychiatrist, we provide compassionate, evidence-based care tailored to your needs. With six outpatient clinics across South and Central Florida and convenient telehealth options, our team of experienced providers is here to help you explore the best treatment path for your mental health.
Contact us today to schedule an appointment and learn more about whether Emsam might be a good fit for you.
Sources:
EMSAM Official Website – Selegiline Transdermal SystemMayo Clinic – Selegiline Transdermal Route: Uses and Side Effects MedlinePlus – Selegiline Transdermal Patch: Drug Information
WebMD – Emsam (Selegiline) Transdermal: Uses, Side Effects, and More
FDA – Emsam (Selegiline Transdermal System) Prescribing Information
