
Anxiety affects millions of people each year, showing up in different ways like constant worry, panic attacks, or physical symptoms like racing heart or restlessness. While many treatments exist, one medication sometimes considered in certain cases is Wellbutrin. But can Wellbutrin really help with anxiety?
What Is Wellbutrin?
Wellbutrin is the brand name for bupropion, a prescription medication most commonly used to treat depression and to help people stop smoking. It works differently from traditional antidepressants like SSRIs (such as Prozac or Zoloft). Wellbutrin primarily affects dopamine and norepinephrine, two chemicals in the brain that play a role in mood and energy levels.
Anxiety and How It Affects the Mind and Body
Anxiety disorders can range from generalized anxiety disorder (GAD) to panic disorder, social anxiety, and phobias. Symptoms often include excessive fear or worry, trouble sleeping, irritability, muscle tension, and even shortness of breath. Living with anxiety can be exhausting, but treatment options are available and effective.
Can Wellbutrin Help with Anxiety?
Wellbutrin isn’t typically a first-line treatment for anxiety. In fact, for some people, especially those with panic disorder or generalized anxiety, Wellbutrin can initially increase anxiety symptoms. However, in others—especially those who have both depression and anxiety—it can improve overall mood, energy, and concentration, which may indirectly ease anxiety over time.
Every person responds differently to medication. This is why working with a psychiatrist is so important.
The Role of Psychiatry in Treating Anxiety
Psychiatrists are medical doctors who specialize in mental health and are trained to evaluate, diagnose, and treat anxiety disorders. At My Psychiatrist, our providers work closely with patients to understand their symptoms, history, and goals to create a personalized treatment plan.
This plan may include:
- Medication: Antidepressants like SSRIs (Selective Serotonin Reuptake Inhibitors) are commonly prescribed for anxiety. In some cases, medications like Wellbutrin (bupropion), which primarily targets dopamine and norepinephrine, may be used off-label when other treatments haven’t worked or if depression co-occurs.
- Talk Therapy: Approaches like Cognitive Behavioral Therapy (CBT) are highly effective in helping individuals identify and reframe anxious thoughts, build coping skills, and reduce avoidance behaviors.
- Lifestyle Changes: Regular exercise, quality sleep, a healthy diet, and reducing caffeine or alcohol intake can all play a powerful role in managing anxiety symptoms.
- Holistic Approaches: Techniques like mindfulness, meditation, yoga, and breathing exercises can complement traditional treatments and support emotional balance.
A psychiatrist can monitor how you’re responding to treatment and make adjustments as needed.

Consult a Licensed Psychiatrist
Wellbutrin may help some individuals with anxiety, especially if depression is also present, but it’s not the standard go-to medication for anxiety disorders. Consulting with a licensed psychiatrist is the best way to determine the most effective treatment for your specific needs.
If you’re struggling with anxiety, My Psychiatrist is here to help. With six outpatient locations across South and Central Florida, our team is ready to support your journey toward better mental health.
FAQs About Wellbutrin and Anxiety
1. Is Wellbutrin approved for anxiety?
No, Wellbutrin is not FDA-approved specifically for anxiety. It’s primarily used for depression and smoking cessation, though it may be prescribed off-label in some anxiety cases.
2. Can Wellbutrin make anxiety worse?
Yes, especially when starting the medication. Some people report increased nervousness or restlessness early in treatment.
3. Why would a psychiatrist prescribe Wellbutrin for someone with anxiety?
If someone has both depression and anxiety, or hasn’t responded well to SSRIs, a psychiatrist might consider Wellbutrin as part of the treatment plan.
4. How long does it take to see results?
It usually takes a few weeks to notice changes in mood or anxiety symptoms. Always follow your provider’s guidance during this time.
5. What are alternatives to Wellbutrin for anxiety?
Other common medications include SSRIs, SNRIs, and benzodiazepines (for short-term use). Non-medication options like therapy, lifestyle changes, and TMS (Transcranial Magnetic Stimulation) are also effective.
Sources:
Healthline – “Wellbutrin Anxiety: What’s the Link?”. https://www.healthline.com/health/anxiety/wellbutrin-anxiety
Verywell Mind – “What to Know About Wellbutrin (Bupropion)” https://www.verywellmind.com/wellbutrin-bupropion-side-effects-1066745
Mayo Clinic – “Bupropion (Oral Route) – Description and Brand Names”. https://www.mayoclinic.org/drugs-supplements/bupropion-oral-route/description/drg-20062478
National Alliance on Mental Illness (NAMI) – “Bupropion (Wellbutrin)”. https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Bupropion-(Wellbutrin)